Objectives: The study of Thyroid Stimulating Hormone level and to find the prevalence of hypo and hyperthyroidism in middle age group of Males and females and Comparison between them. Setting: significance of TSH level in Diagnosis of Hypo and Hyper thyroidism. Design: The study involved 498 suspected cases of thyroid dysfunction ranging in the age group 25 to 50 years only at SSIMS&RC, Davanagere, Karnataka, South India. Duration of the Study: January 2009 to December 2009. Material and methods: The inclusion criteria adapted were age group 25-50 years, newly diagnosed and untreated cases for hypo and hyperthyroidism. Data about the patient age, sex, clinical symptoms confirmed directly by the patients were collected by a pretested and pre diagnosed proforma with informed consent from the patient. 5ml of blood sample was collected from each patient after an overnight past serum was used to estimate TSH level by using Chemilumiscent method. Results: Out of 498 suspected case of thyroid dysfunction 131 were found to be actually suffering from the diseases as confirmed by TSH concentration level. About 83 (15.33%) of 113 females were suffered from Hypothyroidism and other 30 (05.99%) from hyperthyroidism. About 15 (3.01%) of 19 males were suffered from hypothyroidism and 4 (01.13%) were suffered by hyperthyroidism. Hypo and Hyperthyroidism were maximum in the age group of 35-44 years of 42.17% and 25-34 years about 60% in the females and that in males were between the age group 25-34 years and above 45 years of 42.86% and 50% in 25-34 years age group respectively. Conclusion: Significant of Hypo and Hyperthyroidism is more predominant in middle age groups of both male and female.
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